圖 2. 不同強(qiáng)制降解條件下，1 mg/mL 頭孢吡普溶液分離所得降解產(chǎn)物（DPs）的疊加色譜圖。

(A) 10% DMSO 中，在 254 nm 光照下降解 6 h；

(B) 0.01 M NaOH 中堿水解 45 min；

(C) 10% DMSO 中于 3% H?O? 氧化 90 min；

(D) 10% DMSO 中 70 °C 熱降解 270 min；

(E) 0.1 M HCl 中酸水解 6 h；

(F) 10% DMSO 中未降解的頭孢吡普溶液。

Figure 1. Overlaid chromatograms obtained by the separation of degradation products (DPs) of a 1 mg/mL ceftobiprole solution formed in different stress-testing studies: (A)photolysis for 6 h at 254 nm in 10% DMSO; (B) alkaline hydrolysis in 0.01 M NaOH for 45 min; (C) oxidation in 3% H2O2 in 10% DMSO for 90 min; (D) thermolysis at 70 C for 270 min in 10% DMSO; (E) acidic hydrolysis in 0.1 M HCl for 6 h; (F) non-degraded solution of ceftobiprole in 10% DMSO. The first letter of the acronyms describing the DPs comes from the degradation conditions under which they were obtained (A—acidic, B—basic, O—oxidative, P—photolytic), and the acronym SBP denotes synthesis by-products.